Recommend RNA Biology to your librarian for 2008. Download form here.
Sign up for Table of Contents Alerts!
Email this page
Print this page
Review
A Cup Full of Functions
Federica Piccioni, Vincenzo Zappavigna and Arturo C. Verrotti
volume 2 | issue 4
october/november/december 2005Pages: 125 - 128
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.
Data from different laboratories have recently indicated that Cup is a multi-functional protein acting both during Drosophila ovary development and early embryogenesis. Cup directly and/or indirectly affects the activity of different mRNAs and proteins to achieve a broad range of biological functions: I) Cup interacts with Nanos to promote maintenance and survival of the female germ-line stem cells; II) it binds eIF4E and 3’-UTR-bound factors to repress translation of oskar and nanos mRNAs; III) it interacts genetically with eIF4E to control translation initiation during ovary development and growth; IV) it may play a role in the control of the phosphorylation status of eIF4E within the developing ovary; finally, V) it possesses nucleo-cytoplasmic shuttling properties thus pointing to a still uncharacterized function in the cell nucleus. A multi-disciplinary approach, ranging from genetics to proteomics, will be required to shed light on the diverse molecular mechanisms involving Cup and the growing family of its specific interactors.
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.