José Eduardo Kroll,
Pedro A.F. Galante,
Daniel T. Ohara,
Fábio C.P. Navarro,
Lucila Ohno-Machado,
*
Sandro J. de Souza
Pages 1339 - 1343
Keywords:
alternative splicing,
bioinformatics,
combined alternative splicing events,
database,
method of analysis,
next-generation sequencing,
regular expressions
Abstract:
Understanding alternative splicing is crucial to elucidate the mechanisms behind several biological phenomena, including diseases. The huge amount of expressed sequences available nowadays represents an opportunity and a challenge to catalog and display alternative splicing events (ASEs). Although several groups have faced this challenge with relative success, we still lack a computational tool that uses a simple and straightforward method to retrieve, name and present ASEs. Here we present SPLOOCE, a portal for the analysis of human splicing variants. SPLOOCE uses a method based on regular expressions for retrieval of ASEs. We propose a simple syntax that is able to capture the complexity of ASEs.
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