miRNA goes nuclear

* Vera Huang, * Long-Cheng Li     Pages 269 - 273
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Submitted
December 13, 2011
Revised
January 11, 2012
Accepted
January 13, 2012

Keywords: Argonaute proteins, RNA activation, chromatin remodeling, gene regulation, promoter-targeting miRNAs, transcriptional gene silencing

  Abstract: microRNAs (miRNAs), defined as 21–24 nucleotide non-coding RNAs, are important regulators of gene expression. Initially, the functions of miRNAs were recognized as post-transcriptional regulators on mRNAs that result in mRNA degradation and/or translational repression. It is becoming evident that miRNAs are not only restricted to function in the cytoplasm, they can also regulate gene expression in other cellular compartments by a spectrum of targeting mechanisms via coding regions, 5′ and 3′untransalated regions (UTRs), promoters, and gene termini. In this point-of-view, we will specifically focus on the nuclear functions of miRNAs and discuss examples of miRNA-directed transcriptional gene regulation identified in recent years.

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miRNA goes nuclear
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