An understanding of the role of ribonucleic acid (RNA) within the cell has changed dramatically in recent years. Its status expanded with reports of catalytic RNA 20 years ago, of endogenous RNA interference 10 years later and noncoding RNAs very recently. Now there are a lot of data which suggest that RNA is not merely the intermediary between DNA and protein, but the functional end product. Diverse eukaryotic organisms harbor a class of noncoding, small RNAs which are thought to function as regulators of gene expression. Noncoding RNAs play a key role in many steps of epigenetic regulation. There are antisense transcripts that can bind by Watson-Crick interactions functional transcripts and short RNA transcripts that are complementary to repeats throughout the genome. It seems that RNA provides the command and control of cells. Some of the noncoding RNAs associate with human diseases.
RNA Biology is an excellent medium to discuss the current thinking on RNA, from coding and noncoding to therapeutic strategies based on that still very magic molecule. Our journal will emphasize RNA regulatory mechanisms (both natural and potentially therapeutic) and genomics as well as include post-transcriptional regulation at the mRNA level, even if a non-coding RNA is not involved. The scope would therefore cover non-coding RNAs, non-coding regions in mRNAs, and RNA-binding proteins.
This multidisciplinary journal publishes original research articles and reviews covering the latest aspects of molecular, biological and biomedical studies of genomic RNA. We will also include timely minireviews that reflect the broad scope of the journal. The goal is to foster communication and rapid exchange of information through timely publication of important results using traditional as well as electronic formats.