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Short Communication

Small interfering peptides as a novel way of transcriptional control

Ju Yun, Sang-Gyu Kim, Shinyoung Hong and Chung-Mo Park

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Transcription factors are key components of transcriptional regulatory networks governing virtually all aspects of plant growth and developmental processes. Their activities are regulated at various steps, including gene transcription, posttranscriptional mRNA metabolism, posttranslational modifications, nucleocytoplasmic transport, and controlled proteolytic cleavage of membrane-anchored, dormant forms. Dynamic protein dimerization also plays a critical role in this process. An exquisite regulatory scheme has recently been proposed to modulate the action of transcription factors. Small peptides possessing a protein dimerization motif but lacking the DNA-binding motif form nonfunctional heterodimers with a group of specific TFs, inhibiting their transcriptional activation activities. Extensive searches for small proteins that have a similar structural organization in the databases revealed that small peptide-mediated transcription control is not an exceptional case but would be a regulatory mechanism occurring widespread in the Arabidopsis genome.

Authors

Ju Yun

Seoul National University

Sang-Gyu Kim

Seoul National University

Shinyoung Hong

Seoul National University

Chung-Mo Park

Molecular Signaling Laboratory, Department of Chemistry, Seoul National University

Purchase article for $19

Subscribe to this journal for $79/year