Article Addendum

ELF4 as a Central Gene in the Circadian Clock

Volume 2, Issue 5   September/October 2007
Pages 370 - 372
http://dx.doi.org/10.4161/psb.2.5.4463
Authors: Elsebeth Kolmos and Seth J. Davis

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Abstract:

The light-dark cycle of the environment serves as one of the major Zeitgebers in entrainment of the circadian clock. The circadian system consists of interconnected feedback loops in which the CCA1/LHY-TOC1 loop has a central position. Genetic analyses of the elf4 mutant suggested that it is a positive regulator of CCA1 and LHY expression. Recently, we refined the mode-of-action of ELF4 in entrainment of the clock, and here hypothesize that ELF4 expression is interlocked with the CCA1/LHY-TOC1 loop.

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