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Article Addendum

Homologues of Arabidopsis Microtubule-Associated AIR9 in Trypanosomatid Parasites: Hints on Evolution and Function

Henrik Buschmann, Luis Sanchez-Pulido, Miguel A. Andrade-Navarro and Clive W. Lloyd

volume 2 | issue 4

july/august 2007
Pages: 296 - 299

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AIR9 is an essential microtubule-associated protein from Arabidopsis. Sequence similarity searches indicate homologues of AIR9 in land plants and in excavate protists, including trypanosomatid parasites and Trichomonas. The AIR9-like protein from Trypanosoma brucei was recently detected in the proteome of the trypanosome flagellum, raising the possibility that trypanosomatid AIR9-like proteins also associate with microtubules. Because microtubule functions are essential to the viability of trypanosomatid parasites AIR9-like proteins may be exploited as drug targets without homology in humans. We further discuss the unexpected phylogeny of AIR9-like proteins from plants and protozoans.

Authors

Henrik Buschmann

John Innes Centre, Norwich, UK

Luis Sanchez-Pulido

Centro Nacional de Biotecnologia, Madrid, Spain

Miguel A. Andrade-Navarro

Ottawa Health Research Institute, Ottawa, ON, CA

Clive W. Lloyd