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Article Addendum
The TWISTED DWARF’s ABC: How Immunophilins Regulate Auxin Transport
Aurélien Bailly, Valpuri Sovero and Markus Geisler
volume 1 | issue 6
november/december 2006Pages: 277 - 280
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There is increasing evidence that immunophilins function as key regulators of plant development. One of the best investigated members, the multi-domain FKBP TWISTED DWARF1 (TWD1)/FKBP42, has been shown to reside on both the vacuolar and plasma membranes where it interacts in mirror image with two pairs of ABC transporters, MRP1/ MRP2 and PGP/ PGP19(MDR1), respectively. Twisted dwarf1 and pgp1/pgp19 mutants display strongly overlapping phenotypes, including reduction and disorientation of growth, suggesting functional interaction.
In a recent work using plant and heterologous expression systems, TWD1 has been demonstrated to modulate PGP-mediated export of the plant hormone auxin, which controls virtually all plant developmental processes. Here we summarize recent molecular models on TWD1 function in plant development and PGP-mediated auxin tranport and discuss open questions.
Authors
Aurélien Bailly
University of Zurich, Institute of Plant Biology, Zurich, Switzerland
Valpuri Sovero
University of Zurich, Institute of Plant Biology, Zurich, Switzerland
Markus Geisler
University of Zurich, Institute of Plant Biology, Zurich, Switzerland
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.