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Cellular prion protein null mice display normal AMPA receptor mediated long term depression

Houman Khosravani, Yunfeng Zhang and Gerald W. Zamponi

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Cellular prion protein (PrPC) appears to be involved in numerous physiological processes. We have recently shown a novel modulation of NMDA receptors by PrPC that results in neuroprotection via silencing of NMDA receptors containing NR2D subunits, whereas no effects on AMPA receptor function could be observed (Khosravani et al. 2008, J Cell Biol. 181, 551). Here we show that PrP-null mice show a normal response to long-term depression stimuli requiring AMPA receptor activity, thus further supporting our previous findings of a selective action on NMDA receptors among ionotropic glutamate receptors.

Authors

Houman Khosravani

University of Calgary

Yunfeng Zhang

University of Calgary

Gerald W. Zamponi

University of Calgary

Purchase article for $19

Subscribe to this journal for $59/year