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A Short History of Small s: A Prion of the Fungus Podospora anserina
Sven J. Saupe
volume 1 | issue 2
April/May/June 2007Pages: 110 - 115
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Prions are infectious proteins. In fungi, prions correspond to non-Mendelian genetic elements whose mode of inheritance has long eluded explanation. The [Het-s] cytoplasmic genetic element of the filamentous fungus Podospora anserina, was originally identified in 1952 and recognized as a prion nearly half a century later. The present Chapter will attempt to describe the work on [Het-s] from a historical perspective. The initial characterization and early genetic and physiological studies of [Het-s] are described together with the isolation of [Het-s] encoding gene. More recent work that led to the construction of a structural model for this prion is also discussed.
Authors
Sven J. Saupe
CNRS Université de Bordeaux 2
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.