Table of Contents

Volume 6, Issue 1

  January/February/March 2012

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PERSPECTIVE

Harnessing prions as test agents for the development of broad-range disinfectants

Katja Wagenführ and Michael Beekes





MEETING REPORT

Global Alzheimer Research Summit: Basic and clinical research: Present and future Alzheimer research

Danielle Gonsalves, Katarina Jovanovic, Bianca Da Costa Dias and Stefan F.T. Weiss





COMMENTARIES & VIEWS

Open Access Article

Lichens: Unexpected anti-prion agents?

Cynthia M. Rodriguez, James P. Bennett and Christopher J. Johnson


Chronic wasting disease: Fingerprinting the culprit in risk assessments

Martin L. Daus and Michael Beekes


Two-steps control of cellular prion physiology by the Extracellular Regulated Kinase-1 (ERK1)

Frédéric Checler


Insights into the disparate action of osmolytes and macromolecular crowders on amyloid formation

Shahar Sukenik and Daniel Harries


Misfolded PrP and a novel mechanism of proteasome inhibition

Ralph Andre and Sarah J. Tabrizi


Early structural features in mammalian prion conformation conversion

Giuseppe Legname


Ion channels induced by the prion protein: Mediators of neurotoxicity

Isaac H. Solomon, Emiliano Biasini and David A. Harris





RESEARCH PAPERS

Comparative peptidome analyses of the profiles of the peptides ranging 
from 1­–10 KD in CSF samples pooled from probable sporadic CJD 
and non-CJD patients

Cao Chen, Di Xiao, Wei Zhou, Yong-Chan Zhang, Qi Shi, Chan Tian, Jin Zhang, Chun-Xi Zhou, Jian-Zhong Zhang and Xiao-Ping Dong


Salivary prions in sheep and deer

Gültekin Tamgüney, Jürgen A. Richt, Amir N. Hamir, Justin J. Greenlee, Michael W. Miller, Lisa L. Wolfe, Tracey M. Sirochman, Alan J. Young, David V. Glidden, Natrina L. Johnson, Kurt Giles, Stephen J. DeArmond and Stanley B. Prusiner


Therapeutic effect of CHF5074, a new γ-secretase modulator, in a mouse model of scrapie

Giorgio Poli, Erica Corda, Barbara Lucchini, Maria Puricelli, Piera Anna Martino, Paola Dall’Ara, Gino Villetti, Silvio R. Bareggi, Cristiano Corona, Elena Vallino Costassa, Paola Gazzuola, Barbara Iulini, Maria Mazza, Pierluigi Acutis, Paolo Mantegazza, Cristina Casalone and Bruno P. Imbimbo


PRND 3′UTR polymorphism may be associated with behavioral disturbances 
in Alzheimer disease

Marcin Flirski, Monika Sieruta, Ewa Golańska, Iwona Kłoszewska, Paweł P. Liberski and Tomasz Sobów


Y145Stop is sufficient to induce de novo generation prions using protein misfolding cyclic amplification

Ahmed Abdallah, Ping Wang, Juergen A. Richt and Srinand Sreevatsan





SHORT COMMUNICATION

Comparative analysis of Japanese and foreign L-type BSE prions

Kentaro Masujin, Ritsuko Miwa, Hiroyuki Okada, Shirou Mohri and Takashi Yokoyama