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Role of peroxiredoxin III in the pathogenesis of pre-eclampsia as evidenced in mice

Li Lianqin, Masuo Obinata and Katsuyoshi Hori

As a member of peroxiredoxin (Prx) family, PrxIII has been demonstrated to play an important role in scavenging intracellular reactive oxygen species (ROS). Since PrxIII knockout mice exhibited oxidative stress in placentas resembling pathophysiologic changes in placentas of human pre-eclampsia, we measured blood pressure through the carotid artery and detected oxidative status by Western blotting in pregnant mice. We did not notice hypertension in pregnant PrxIII knockout mice as compared with wild-type littermates, although endothelin-1 was over-expressed in PrxIII-deficient placentas. Our results indicate that PrxIII is not involved in pre-eclamptic development. Instead, PrxIII is an indispensable antioxidant in placentas where oxidative stress exists.

Authors

Li Lianqin Corresponding author: lilq2005@126.com

Obstetrics and Gynecology Center, Tsinghua University Second Hospital; Beijing, China

Masuo Obinata

Department of Cell Biology, Institute of Development, Aging, and Cancer; Tohoku University; Sendai, Japan

Katsuyoshi Hori

Department of Vascular Biology, Institute of Development, Aging, and Cancer; Tohoku University; Sendai, Japan