Recommend Organogenesis to your librarian for 2008. Download form here.
Sign up for Table of Contents Alerts.
Email this page
Print this page
Review Series: Fetal Programming
Blood pressure follows the kidney: Perinatal influences on hereditary hypertension
Maarten P. Koeners, Branko Braam and Jaap A. Joles
volume 4 | issue 3
july/aug/sepSubscribe to this journal for $59/year
Epidemiological and experimental data strongly suggest that cardiovascular diseases can originate from an aberrant environment during fetal development, a phenomenon referred to as perinatal programming. This review will focus on the role of the kidneys in determining blood pressure, and how (re)programming the renal development can persistently ameliorate hereditary hypertension. By combining physiologic and genomic studies we have discovered some candidate pathways suited for (re)programming the development of hypertension. This sets the stage for mechanistic analysis in future studies.
Authors
Maarten P. Koeners
Department of Nephrology and Hypertension; University Medical Center; Utrecht, The Netherlands
Branko Braam
University Alberta; Edmonton, Alberta, Canada
Jaap A. Joles
Department of Nephrology and Hypertension; University Medical Center; Utrecht, The Netherlands