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Organogenesis Forum
Organogenesis forum lecture: In vitro kidney development and tissue engineering
Sanjay K. Nigam, Wei Wu and Kevin T. Bush
volume 4 | issue 3
july/august/septemberPages: 137 - 143
This is an open-access article
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Renal replacement therapy (i.e., kidney transplantation) represents the optimal treatment for end-stage renal disease (a condition which is expected to increase over the next decade or so). However, the demand for transplantable kidneys currently outpaces the availability of donor kidneys, a situation not expected to improve in the foreseeable future. An alternative route to cadaveric or living-related donors would be to engineer kidneys for allograft transplantation from cells based on concepts derived from our current understanding of normal kidney development. Although the use of cells for this purpose remains hypothetical, recent research from our laboratory has provided strong evidence that implantation of kidney-like tissue bio-engineered from the recombination of in vitro culture systems which model discrete aspects of kidney development (i.e., cell culture, isolated WD, isolated UB, and isolated MM) is possible. These recent findings are discussed here. Pathway based system biology approaches to understanding the mechanism(s) of kidney development are also discussed, particularly in the setting of this novel and seemingly powerful xeno-based tissue engineering strategy.
Authors
Sanjay K. Nigam
School of Medicine; University of California at San Diego; La Jolla, California USA
Wei Wu
School of Medicine; University of California at San Diego; La Jolla, California USA
Kevin T. Bush
School of Medicine; University of California at San Diego; La Jolla, California USA
This is an open-access article
Download PDFIf the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.