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Review

Wnt signaling in breast organogenesis

Kata Boras-Granic and John J. Wysolmerski

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Wnt signals play a critical role in regulating the normal development of the mammary gland and dysregulation of Wnt signaling causes breast cancer. This pathway is involved in the earliest development of the mammary gland in embryos and its role extends through the functional differentiation of the gland during pregnancy. In this review, we summarize the molecular mechanisms through which Wnts regulate mammary gland development in the mouse.

Authors

Kata Boras-Granic

Section of Endocrinology and Metabolism; Department of Internal Medicine; Yale University, New Haven, Connecticut USA

John J. Wysolmerski

Section of Endocrinology and Metabolism; Department of Internal Medicine; Yale University, New Haven, Connecticut USA

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