Planar cell polarity signaling in craniofacial development
Volume 7, Issue 4
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Pages 255 - 259http://dx.doi.org/10.4161/org.7.4.18797
Authors: Jacek Topczewski, Rodney M. Dale and Barbara E. Sisson View affiliations
Out of the several signaling pathways controlling craniofacial development, the role of planar cell polarity (PCP) signaling is relatively poorly understood. This pathway, originally identified as a mechanism to maintain cell polarity within the epithelial cells of the Drosophila wing, has been linked to the proper development of a wide variety of tissues in vertebrates and invertebrates. While many of the pathway members are conserved, it appears that some of the members of the pathway act in a tissue-specific manner. Here, we discuss the role of this pathway in vertebrate craniofacial development, highlighting cranial neural crest migration, skull and palate formation and the role of non-traditional modulators of PCP signaling within this developmental process.
Received: September 15, 2011; Accepted: November 17, 2011