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Review: Epigenetics in Organ Development
The making of an organ: RNA mediated developmental controls in mice
Minoo Rassoulzadegan and François Cuzin
Volume 6, Issue 1January/February/March 2010
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Based initially on the observation of inheritance patterns at variance with Mendel’s first law, hereditary epigenetic variations were evidenced in the mouse. Modulating the transcription of a locus, they are induced by RNAs with sequence homology to the transcript. RNAs transferred by the gamete, including sperm, to the fertilized egg appeared to be responsible for transgenerational maintenance of the variant phenotypes. Instances of RNA-dependent variations so far analyzed in the mouse—a pathological deviation of heart development and a syndrom of gigantism initiated by hyperproliferation of embryonic stem cells—suggest a general dependence of organogenesis on epigenetic controls of gene expression.
Authors
- Minoo Rassoulzadegan Corresponding author: minoo@unice.fr
- Inserm U636; Nice, France
- François Cuzin
- Inserm U636; Nice, France
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