Authors: David A. Hill and David Artis

David A. Hill

Department of Microbiology; Perelman School of Medicine; University of Pennsylvania; Philadelphia, PA USA; Institute for Immunology; Perelman School of Medicine; University of Pennsylvania; Philadelphia, PA USA; Department of Pathobiology; School of Veterinary Medicine; University of Pennsylvania; Philadelphia, PA USA

David Artis

Corresponding author: dartis@mail.med.upenn.edu
Department of Microbiology; Perelman School of Medicine; University of Pennsylvania; Philadelphia, PA USA; Institute for Immunology; Perelman School of Medicine; University of Pennsylvania; Philadelphia, PA USA; Department of Pathobiology; School of Veterinary Medicine; University of Pennsylvania; Philadelphia, PA USA

Abstract:
Commensal bacteria that colonize mammalian mucosal surfaces are reported to influence T helper type 2 (T_H2) cytokine-dependent inflammation and susceptibility to allergic disease. However, the mechanisms that underlie these observations are only beginning to be understood. We recently utilized studies of murine model systems and atopic patient populations to elucidate a mechanism by which commensal bacteria-derived signals limit serum immunoglobulin E levels, influence basophil development and steady-state circulating basophil populations and regulate basophil-associated T_H2 cell responses and allergic inflammation. In this addendum, we summarize the findings of our recent work and other developments in the field, discuss the broader implications of these findings and generate new hypotheses regarding our understanding of host-commensal relationships. These areas of investigation may be applicable to the development of new preventative or therapeutic approaches to reduce the burden of allergic disease.

Article Addendum to:
DA Hill, MC Siracusa, MC Abt, BS Kim, D Kobuley, M Kubo, T Kambayashi, DF Larosa, ED Renner, JS Orange, FD Bushman, D Artis. Commensal bacteria-derived signals regulate basophil hematopoiesis and allergic inflammation. Nat Med 2012; 18: 538-46
PMID: 22447074 DOI: 10.1038/nm.2657

Received: June 26, 2012; Accepted: November 2, 2012; Published Online: November 8, 2012

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