Review
Gut microbial communities modulating brain development and function
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Pages 366 - 373
http://dx.doi.org/10.4161/gmic.21287
Keywords: behavior, brain development, gut microbiota, microbiota-gut-brain axis, probiotics
Authors: Maha Al-Asmakh, Farhana Anuar, Fahad Zadjali, Joseph Rafter and Sven Pettersson
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Abstract:
Mammalian brain development is initiated in utero and internal and external environmental signals can affect this process all the way until adulthood. Recent observations suggest that one such external cue is the indigenous microbiota which has been shown to affect developmental programming of the brain. This may have consequences for brain maturation and function that impact on cognitive functions later in life. This review discusses these recent findings from a developmental perspective.
Received: July 4, 2011; Accepted: June 27, 2012; Published Online: June 29, 2012
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