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Flies on the Net
Computational Identification of Site-Specific Transcription Factors in Drosophila
Boris Adryan and Sarah A. Teichmann
volume 1 | issue 3
May/June 2007Pages: 142 - 145
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Site-specific transcription factors (TFs) recognise their target genes in a sequence- or conformation-dependent manor. In contrast to the basal TFs that are the general facilitators of gene expression, their site-specific interaction partners are tissue- or condition-specific. Thus, site-specific TFs constitute the major prerequisite for the modular expression programmes that drive metazoan development. This article deals with the computational identification of TFs (how to find them in genomes) and with online resources such as the FlyTF database of Drosophila site-specific TFs (how to find them online).
Authors
Boris Adryan
Theoretical & Computational Biology; MRC Laboratory of Molecular Biology; Cambridge UK
Sarah A. Teichmann
Theoretical & Computational Biology; MRC Laboratory of Molecular Biology; Cambridge UK
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.