Methods and Technical Advances

A database for the analysis of immunity genes in Drosophila: PADMA database

Volume 5, Issue 2   April/May/June 2011
Pages 155 - 161
http://dx.doi.org/10.4161/fly.5.2.14674
Authors: Mark J. Lee, Ariful Mondal, Chiyedza Small, Indira Paddibhatla, Akira Kawaguchi and Shubha Govind

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Abstract:
While microarray experiments generate voluminous data, discerning trends that support an existing or alternative paradigm is challenging. To synergize hypothesis building and testing, we designed the Pathogen Associated Drosophila MicroArray (PADMA) database for easy retrieval and comparison of microarray results from immunity-related experiments (www.padmadatabase.org). PADMA also allows biologists to upload their microarray-results and compare it with datasets housed within PADMA. We tested PADMA using a preliminary dataset from Ganaspis xanthopoda-infected fly larvae, and uncovered unexpected trends in gene expression, reshaping our hypothesis. Thus, the PADMA database will be a useful resource to fly researchers to evaluate, revise, and refine hypotheses.

Received: December 21, 2010; Accepted: January 3, 2011

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