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Research Paper
Long-Range Allosteric Interactions between the Folate and Methionine Cycles Stabilize DNA Methylation Reaction Rate
H. Frederik Nijhout, Michael C. Reed, David F. Anderson, Jonathan C. Mattingly, S. Jill James and Cornelia M. Ulrich
volume 1 | issue 2
april/may/june 2006Pages: 81 - 87
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Several metabolites in the folate and methionine cycles influence the activities of distant enzymes involved in one-carbon metabolism. Many hypotheses have been advanced about the functional impact of these long-range interactions. Using both steady-state and fluctuation analyses of a mathematical model of methionine metabolism, we investigate the biochemical basis for several of these hypotheses. We show that the long-range interactions provide remarkable stabilization of the DNA methylation rate in the face of large fluctuations in methionine input. In particular, they enable the system to maintain methylation in the face of low and extremely low protein input. These interactions may therefore have evolved primarily to stabilize DNA methylation under conditions of methionine starvation. In silico experimentation allows us to evaluate the independent effects of various combinations of the long-range interactions, and thereby propose a plausible evolutionary scenario.
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.