There is strong evidence indicating that disease in adult humans stems from a combination of genetic and environmental factors. A problem in identifying environmental factors is that subacute exposures during early life are often unnoticed, or exposures are variable among a diverse population. This leads to a confusing pattern in adulthood. An additional problem in following exposure effects in humans is the length of time needed to study outcomes spanning a human generation. We have recently developed a zebrafish model for studying the effects of sublethal juvenile exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin). Although the initial exposure produces no effect at the time, we find skeletal and reproductive defects in adulthood and into subsequent generations. The short generation time of zebrafish along with the ability to maintain large cohorts of exposed individuals and their offspring allows us to overcome variation in exposure and genetic background. Here we describe progress in studying TCDD as an endocrine and developmental disruptor, and our results showing adult consequences of early exposure.
Endocrine Disruptors is published as a fully open access, online-only journal. This allows authors free access to and distribution of published articles.
The first issue of this new journal will be published in 2013.
Endocrine Disruptors is a unique focus peer-reviewed journal with a broad international audience. It will publish high-quality research addressing all aspects of how endocrine-active contaminants dupe the hormonal signaling system into inappropriate communication, and how we can intervene. The goal of our journal is to present top-notch and thought-provoking papers that will provide a better understanding of how these compounds operate. Such understanding will lead to solutions that address the hazards that endocrine disruptors pose to humans, wildlife, and the environment.
The Online Only Journal Endocrine Disruptors is now accepting submissions! Endocrine Disruptors utilizes an online submission and tracking system designed to provide efficient service to authors. Through the online system, author files are automatically converted to PDFs, submissions are acknowledged by email, and authors can track their manuscript through the stages of the peer review process. For additional information on how to submit your manuscript, please click here.