CSSN: ISSN 1000-467X CODEN: AIZHENG4 CN: 44-1195/R

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Clinical Research Paper

Occurrence and Influencing Factors of Paranasal Sinusitis in Nasopharyngeal Carcinoma Patients after Radiotherapy

Tai-Ze Yuan, Xiang Guo, Lie Zheng, Su-Mei Cao, Ning-Wei Li and Yan-Qun Xiang

volume 27 | issue 8

August 2008
Pages: 165 - 168

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Background and Objective: Radiation usually results in paranasal sinusitis in nasopharyngeal carcinoma (NPC) patients, which influences patient’s quality of life. This study was to explore the occurrence and influencing factors of paranasal sinusitis in NPC patients before and after radiotherapy. Methods: Clinical data of 381 NPC patients, treated in Cancer Center of Sun Yat-sen University from January 1998 to July 2000, were reviewed. CT images before and after radiotherapy were compared. The occurrence and influencing factors of paranasal sinusitis were analyzed. Results: Of the 381 NPC patients, 176 (46.2%) suffered from paranasal sinusitis before radiotherapy. Among the 205 NPC patients without paranasal sinusitis before radiotherapy, 103 (50.2%) developed paranasal sinusitis after radiotherapy; the occurrence rates of paranasal sinusitis at 1st month, 3rd month, 6th month, and 1st year after radiotherapy were 21.0%, 33.7%, 41.5% and 29.3%, respectively (χ2 = 20.918, p < 0.001). Logistic analysis showed that T stage was related to the occurrence rate of paranasal sinusitis. Conclusion: The incidence of paranasal sinusitis in NPC patients after radiotherapy is high and related to T stage.