CJC is published 12 times a year.
Sign up for Table of Contents Alerts!
Please note: CJC is published in English and Chinese. Manuscripts are published online prior to printing. The citation will change as volume, issue and page numbers are finalized.
Email this page
Print this page
Review
SUMO-Specific Protease 1 and Cancer
Jin-Ke Cheng
volume 27 | issue 7
July 2008Pages: 85 - 87
Subscribe to this journal for $0/year
Post-translational modifiers of the small ubiquitin-like modifier protein (SUMO) family have emerged as key regulators of protein function and localization. SUMO modification is a dynamic process, catalyzed by SUMO-specific E1, E2, and E3s and reversed by a family of SUMO-specific proteases (SENPs). Although six human SENPs have been identified, each with different cellular locations and substrate specificities, the precise roles of SENPs in cellular processes involved has not been well-defined. This brief review will focus on recent advances about the identified targets of SENP1 and its potential role in tumorigenesis.
Authors
Jin-Ke Cheng
Shanghai Jiao Tong University School of Medicine