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Basic Research Paper
Antitumor Effects and Mechanisms of Dendritic Cell Vaccine which Silenced SOCS1 by siRNA, Stimulated by OK432 and Pulsed with Tumor Cell Lysates in Hepatocellular Carcinoma
Hai-Feng Song, Jun Zhou, Ke Pan, Qi-Jing Wang, Hui Wang, Li-Xi Huang, Yong-Qiang Li and Jian-Chuan Xia
volume 27 | issue 7
July 2008Subscribe to this journal for $0/year
Suppressor of cytokine signaling 1 (SOCS1) plays a critical role in antitumor immunity. Down-regulating SOCS1 in antigen-presenting dendritic cells (DCs) could enhance antigen-specific antitumor immunity. This study was to investigate the antigen-specific antitumor effect of SOCS1-silenced DCs which stimulated by OK432 and pulsed with hepatocellular carcinoma cell line HepG2 antigens, and explore the mechanisms.
Authors
Hai-Feng Song
State Key Laboratory of Oncology in South China and Sun Yet-sen University Cancer Center
Jun Zhou
State Key Laboratory of Oncology in South China and Sun Yet-sen University Cancer Center
Ke Pan
State Key Laboratory of Oncology in South China and Sun Yet-sen University Cancer Center
Qi-Jing Wang
State Key Laboratory of Oncology in South China and Sun Yet-sen University Cancer Center
Hui Wang
State Key Laboratory of Oncology in South China and Sun Yet-sen University Cancer Center
Li-Xi Huang
State Key Laboratory of Oncology in South China and Sun Yet-sen University Cancer Center
Yong-Qiang Li
State Key Laboratory of Oncology in South China and Sun Yet-sen University Cancer Center
Jian-Chuan Xia
State Key Laboratory of Oncology in South China and Sun Yet-sen University Cancer Center