CSSN: ISSN 1000-467X CODEN: AIZHENG4 CN: 44-1195/R

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Basic Research Paper

Effects of SB203580 and WP631 on Smad Signal Transduction Pathway in Lung Fibroblasts after Irradiation

Yang Li, Liang-Wen Song, Rui-Yun Peng, De-Wen Wang, Mei-Hong Jin, Ya-Bing Gao and Jun-Jie Ma

volume 27 | issue 7

July 2008

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Radiation pulmonary fibrosis (RPF) is characterized by fibroblast proliferation and excessive accumulation of extra cellular matrix (ECM). Transforming growth factor β (TGFβ) is a switch factor in the initiation and development of RPF and served as a therapeutic target. Blocking TGFβ1 signal transduction pathway might alleviate RPF. This study was to investigate the effects of two TGFβ inhibitors,SB203580 and WP631,on the Smad signal transduction pathway in lung fibroblasts after irradiation.

Authors

Yang Li

Beijing Institute of Radiation Medicine

Liang-Wen Song

Beijing Institute of Radiation Medicine

Rui-Yun Peng

Beijing Institute of Radiation Medicine

De-Wen Wang

Beijing Institute of Radiation Medicine

Mei-Hong Jin

Beijing Institute of Radiation Medicine

Ya-Bing Gao

Beijing Institute of Radiation Medicine

Jun-Jie Ma

Beijing Institute of Radiation Medicine


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