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Basic Research Paper
Effects of SB203580 and WP631 on Smad Signal Transduction Pathway in Lung Fibroblasts after Irradiation
Yang Li, Liang-Wen Song, Rui-Yun Peng, De-Wen Wang, Mei-Hong Jin, Ya-Bing Gao and Jun-Jie Ma
Volume 27, Issue 7July 2008
Pages 25 - 28
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Radiation pulmonary fibrosis (RPF) is characterized by fibroblast proliferation and excessive accumulation of extra cellular matrix (ECM). Transforming growth factor β (TGFβ) is a switch factor in the initiation and development of RPF and served as a therapeutic target. Blocking TGFβ1 signal transduction pathway might alleviate RPF. This study was to investigate the effects of two TGFβ inhibitors，SB203580 and WP631，on the Smad signal transduction pathway in lung fibroblasts after irradiation.
Authors
- Yang Li
- Beijing Institute of Radiation Medicine
- Liang-Wen Song
- Beijing Institute of Radiation Medicine
- Rui-Yun Peng
- Beijing Institute of Radiation Medicine
- De-Wen Wang
- Beijing Institute of Radiation Medicine
- Mei-Hong Jin
- Beijing Institute of Radiation Medicine
- Ya-Bing Gao
- Beijing Institute of Radiation Medicine
- Jun-Jie Ma
- Beijing Institute of Radiation Medicine
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF
If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.
