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Basic Research Paper
Effects of SB203580 and WP631 on Smad Signal Transduction Pathway in Lung Fibroblasts after Irradiation
Yang Li, Liang-Wen Song, Rui-Yun Peng, De-Wen Wang, Mei-Hong Jin, Ya-Bing Gao and Jun-Jie Ma
volume 27 | issue 7
July 2008Subscribe to this journal for $/year
Radiation pulmonary fibrosis (RPF) is characterized by fibroblast proliferation and excessive accumulation of extra cellular matrix (ECM). Transforming growth factor β (TGFβ) is a switch factor in the initiation and development of RPF and served as a therapeutic target. Blocking TGFβ1 signal transduction pathway might alleviate RPF. This study was to investigate the effects of two TGFβ inhibitors，SB203580 and WP631，on the Smad signal transduction pathway in lung fibroblasts after irradiation.
Authors
Yang Li
Beijing Institute of Radiation Medicine
Liang-Wen Song
Beijing Institute of Radiation Medicine
Rui-Yun Peng
Beijing Institute of Radiation Medicine
De-Wen Wang
Beijing Institute of Radiation Medicine
Mei-Hong Jin
Beijing Institute of Radiation Medicine
Ya-Bing Gao
Beijing Institute of Radiation Medicine
Jun-Jie Ma
Beijing Institute of Radiation Medicine