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Current Topics in Ion Channels

TRPC3/6/7: Topical aspects of biophysics and pathophysiology

Petra Eder and Klaus Groschner

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Nonselective and lipid-regulated cation channels formed by TRPC3, TRPC6 and TRPC7 have recently obtained attention in view their potential pathophysiological impact. It appears as a particular challenge to understand the molecular basis of TRPC3/6/7-related diseases in order to further delineate their value as therapeutic targets. The multifunctional nature of these channel proteins, based on a complex, versatile heteromerization potential along with highly promiscuous gating and mixed cation permeation properties, make these channels pivotal players in cellular signalling networks. Here we summarize newsworthy aspects of TRPC3/6/7 Physiology and Pathophysiology that open the view on novel therapeutic strategies based on these TRPCs as target structures.

Authors

Petra Eder

University of Graz

Klaus Groschner

University of Graz

Purchase article for $19

Subscribe to this journal for $79/year