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Article Addendum
The Role of 14-3-3 Dimerization in Its Modulation of the CaV2.2 Channel
Yong Li, Yuying Wu, Rui Li and Yi Zhou
volume 1 | issue 1
January/February 2007Pages: 1 - 2
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Voltage dependent inactivation is an important property of voltage gated calcium channels. Recently, we have reported that 14 3 3 proteins profoundly reduce inactivation of the CaV2.2 channel at both open and closed states. Using a combination of molecular, biochemical and electrophysiological approaches, we have shown that the modulation is mediated by 14 3 3 binding to the carboxyl tail of the CaV2.2 pore forming α1B subunit. In this addendum, we present our new finding that 14 3 3 self dimerization is not required for its modulation of CaV2.2 channel inactivation. These studies will help to understand the molecular mechanism underlying 14 3 3 dependent modulation of CaV2.2 channels.
Authors
Yong Li
Huashan Hospital
Yuying Wu
University of Alabama at Birmingham
Rui Li
University of Alabama at Birmingham
Yi Zhou
University of Alabama at Birmingham
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.