Article Addendum

Regulation of the KV4.2 complex by CaV3.1 calcium channels

Volume 4, Issue 3   May/June 2010
Pages 163 - 167
http://dx.doi.org/10.4161/chan.4.3.11955
Authors: Dustin Anderson, Renata Rehak, Shahid Hameed, W. Hamish Mehaffey, Gerald W. Zamponi and Ray W. Turner

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Abstract:

A-type potassium current generated by the KV4 family of channels is an important factor regulating the frequency, latency and dendritic backpropagation of spike discharge. The KV4.2 complex of KV4.2-KChIP3-DPP10c was recently shown to form a novel signaling complex through its association with T-type CaV3.2 or CaV3.3 calcium channel isoforms. CaV3-mediated calcium entry was shown to selectively right-shift the inactivation voltage of KV4.2 into the physiological range to modulate cerebellar stellate cell latency and gain. We now show that CaV3.1 calcium channels can also associate with the KV4.2 complex to effect similar regulation of KV4.2 inactivation voltage. By comparison, no calcium-dependent shift in KV4.2 inactivation properties was elicited by any of CaV1.4, CaV2.1 or CaV2.3 calcium channels coexpressed with the KV4.2 complex, emphasizing the important role for low voltage-activated CaV3 channels in this signaling complex.

Article Addendum to:
D Anderson, WH Mehaffey, M Iftinca, R Rehak, JD Engbers, S Hameed, GW Zamponi, RW Turner. Regulation of neuronal activity by Cav3-Kv4 channel signaling complexes. Nature Neuroscience 2010; 13: 333-7

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