Review

Roles of E3 ubiquitin ligases in cell adhesion and migration

Volume 4, Issue 1   January/February/March 2010
Pages 10 - 18
http://dx.doi.org/10.4161/cam.4.1.9834
Authors: Cai Huang

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Abstract:
Recent studies have demonstrated that a number of E3 ubiquitin ligases, including Cbl, Smurf1, Smurf2, HDM2, BCA2, SCFβ-TRCP and XRNF185, play important roles in cell adhesion and migration.  Cbl negatively regulates cell adhesion via α integrin and Rap1, and inhibits actin polymerization by ubiquitinating mDab1 and WAVE2.  Smurf1 regulates cell migration through ubiquitination of RhoA, talin head domain and hPEM2, while Smurf2 ubiquitinates Smurf1, TGF-β type I receptor and RaplB to modulate cell migration and adhesion. HDM2 negatively regulates cell migration by targeting NFAT (a transcription factor) for ubiquitination and degradation, while SCFβ-TRCP ubiquitinates Snail (a transcriptional repressor of E-cadherin) to inhibit cell migration. TRIM32 promotes cell migration through ubiquitination of Abl interactor 2 (Abi2), a tumor suppressor.  RNF5 and XRNF185 modulate cell migration by ubiquitinating paxillin.  Thus, theses E3 ubiquitin ligases regulate cell adhesion and (or) migration through ubiquitination of their specific substrates.

Received: April 30, 2009; Accepted: August 18, 2009

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