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Special Focus
Modeling cell migration in 3D: Status and challenges
Rajagopal Rangarajan and Muhammad H. Zaman
volume 2 | issue 2
april/may/june 2008Subscribe to this journal for $59/year
Cell migration is a multi-scale process that integrates signaling, mechanics and biochemical reaction kinetics. Various mathematical models accurately predict cell migration on 2-D surfaces, but are unable to capture the complexities of 3D migration. Additionally, quantitative 3D cell migration models have been few and far between. In this review we look and characterize various mathematical models available in literature to predict cell migration in 3-D matrices and analyze their strengths and possible changes to these models that could improve their predictive capabilities.
Authors
Rajagopal Rangarajan
The University of Texas at Austin
Muhammad H. Zaman
The University of Texas at Austin