Recommend Cell Adhesion & Migration (CAM) to your librarian for 2008. Download form here.
Email this page
Print this page
Review
Cell colonization in degradable 3D porous matrices
Benjamin J. Lawrence and Sundararajan V. Madihally
volume 2 | issue 1
January/February/March 2008Pages: 9 - 16
Subscribe to this journal for $59/year
Cell colonization is an important in a wide variety of biological processes and applications including vascularization, wound healing, tissue engineering, stem cell differentiation, and biosensors. During colonization porous 3D structures are used to support and guide the ingrowth of cells into the matrix. In this review, we summarize our understanding of various factors affecting cell colonization in 3-dimensional environment. The structural, biological, and degradation properties of the matrix all play key roles during colonization. Further, specific scaffold properties such as porosity, pore size, fiber thickness, topography, and scaffold stiffness as well as important cell material interactions such as cell adhesion and mechanotransduction also influence colonization.
Authors
Benjamin J. Lawrence
Oklahoma State University
Sundararajan V. Madihally
Oklahoma State University