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Commentary & View
The Role of PP2A A Subunits in Tumor Suppression
Anna A. Sablina and William C. Hahn
volume 1 | issue 3
July/August/September 2007Pages: 140 - 141
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The protein phosphatase 2A (PP2A) family of heterotrimeric serine-threonine phosphatases participates in human cell transformation. Each functional PP2A complex contains one structural A subunit (Aα or Aβ), and mutations of both are found to occur at low frequency in human tumors. We have shown that Aα functions as haploinsufficient tumor suppressor gene by regulating in part phosphatidylinositol 3-kinase (PI3K signaling). In contrast, loss of Aβ function due to biallelic alterations contributes to cancer progression through dysregulation of small GTPase RalA activity. These observations provide evidence that dysfunction of particular PP2A complexes regulate specific phosphorylation event necessary for cancer initiation.
Authors
Anna A. Sablina
Brigham and Women%u2019s Hospital and Harvard Medical School; Boston, Massachusets USA
William C. Hahn
Brigham and Women%u2019s Hospital and Harvard Medical School; Boston, Massachusets USA; Broad Institute of Harvard and MIT; Cambridge, Massachusets USA
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.