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Desmosomes: Just Cell Adhesion or Is There More?

Ansgar Schmidt and Peter J. Koch

volume 1 | issue 1

January/February/March 2007
Pages: 28 - 32

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Desmosomes are cell adhesion structures (junctions) that are particularly abundant in cells derived from the ectodermal lineages. These junctions are required to maintain the integrity of organs subjected to mechanical stress, in particular the skin and the heart. This conclusion is partially based on tissue fragility phenotypes observed in mice with null mutations in certain desmosomal genes. Furthermore, patients have been identified that develop severe skin disorders, and even fatal heart diseases, due to impaired desmosome function. Nevertheless, desmosomes are more than cellular glue. New evidence suggests that these junctions can transmit signals from the extracellular environment to the nucleus, for example by controling the cytoplasmic pool of transcriptional co-factors that belong to the armadillo family of desmosomal proteins (i.e. plakoglobin, plakophilins). Understanding the signaling properties of desmosomes will provide new insights into developmental processes such as skin and skin appendage development. Furthermore, there is evidence to suggest that abnormal signaling through these junctions contributes to the symptoms of certain skin and heart diseases.

Authors

Ansgar Schmidt

University of Marburg, Marburg, Hessen, Germany

Peter J. Koch

Department of Dermatology, University of Colorado / UCDHSC, Aurora, CO USA

We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link: