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Review
From Tango to Quadrilla: Current Views of the Immunological Synapse
Cristina Mazzon and Antonella Viola
volume 1 | issue 1
January/February/March 2007Pages: 7 - 12
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All T cell functions require establishing contacts with other cells. In the last ten years, the immunological synapse, the contact-site between T cells and their partners, has been the object of numerous investigations and recent advances in imaging technologies have provided significant insights into the mechanism of immunological synapse formation and its functional outcomes. Considering all the available data, the immunological synapse can be defined as a dynamic structure, formed between a T cell and one or more antigen-presenting cells, showing lipid and protein segregation, signaling compartmentalization, and bidirectional information exchange though soluble and membrane-bound transmitters. In this review, we present the current views on the immunological synapse and discuss about some interesting unresolved questions.
Authors
Cristina Mazzon
Istituto Clinico Humanitas IRCCS
Antonella Viola
University of Padova, Padova, Italy
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.