Review

The mesenchymal tumor microenvironment: A drug-resistant niche

Volume 6, Issue 3   May/June 2012
Pages 285 - 296
http://dx.doi.org/10.4161/cam.20210
Keywords: extracellular matrix, matrix-induced drug resistance, mesenchymal stroma, stromal-induced drug resistance, tumor microenvironment, tumor-associated or carcinoma-associated fibroblasts, tumor-stromal interactions
Authors: Edna Cukierman and Daniel E. Bassi

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Abstract:
Drug and radiation resistance represent a challenge for most anticancer therapies. Diverse experimental approaches have provided evidence that the tumor-associated microenvironment constitutes both a protective shell that impedes drug or radiation access and a permissive or promotive microenvironment that encourages a nurturing cancer (i.e., cancer stem cell) niche where tumor cells overcome treatment- and cancer-induced stresses. Better understanding of the effects of the tumor microenvironment on cancer cells before, during and immediately after chemo- or radiotherapy is imperative to design new therapies aimed at targeting this tumor-protective niche. This review summarizes some of the known mesenchymal stromal effects that account for drug resistance, the main signal transduction pathways associated with this resistance and the therapeutic efforts directed to increase the success of current therapies. Special emphasis is given to environment-mediated drug resistance in general and to cell adhesion-mediated drug resistance in particular.

Received: February 7, 2012; Accepted: March 29, 2012; Published Online: May 1, 2012

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