Table of Contents

Volume 6, Issue 24

  December 15, 2007

  Pages 2997 - 3147

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Conceptual Review

• Paradoxes of Aging

  Mikhail V. Blagosklonny
  Pages 2997 - 3003

Extra Views

• A Cul3-Based E3 Ligase Regulates Mitosis and is Required to Maintain the Spindle Assembly Checkpoint in Human Cells

  Izabela Sumara and Matthias Peter
  Pages 3004 - 3010

• All Roads Lead to mTOR: Integrating Inflammation and Tumor Angiogenesis

  Dung-Fang Lee and Mien-Chie Hung
  Pages 3011 - 3014

• Multiple Mechanisms for p27^Kip1 Translocation and Degradation

  Etsuo Susaki and Keiichi I. Nakayama
  Pages 3015 - 3020

• Chemosensitizing Anti-Cancer Activity of LFM-A13, a Leflunomide Metabolite Analog Targeting Polo-like Kinases

  Fatih M. Uckun
  Pages 3021 - 3026

• The Dissection of Human Autosomal Recessive Osteopetrosis Identifies an Osteoclast-Poor Form Due to RANKL Deficiency

  Annalisa Frattini, Paolo Vezzoni, Anna Villa and Cristina Sobacchi
  Pages 3027 - 3033

• Revealing a Role of MicroRNAs in the Regulation of the Biological Clock

  Hai-Ying Mary Cheng and Karl Obrietan
  Pages 3034 - 3038

Perspectives

• CDC25A Levels Determine the Balance of Proliferation and Checkpoint Response

  Open Access Article

  Dipankar Ray and Hiroaki Kiyokawa
  Pages 3039 - 3042

• Regulation of Mitochondrial Morphological Dynamics During Apoptosis by Bcl-2 family proteins: A Key in Bak?

  Craig Brooks and Zheng Dong
  Pages 3043 - 3047

• Does Caspase Inhibition Promote Clonogenic Tumor Growth?

  Ute Fischer, Katja Janssen and Klaus Schulze-Osthoff
  Pages 3048 - 3053

• Prostaglandin E2: Making More of Your Marrow

  Allegra M. Lord, Trista E. North and Leonard I. Zon
  Pages 3054 - 3057

Review

• Phosphatases, DNA Damage Checkpoints and Checkpoint Deactivation

  Johanna Heideker, Ewa T. Lis and Floyd E. Romesberg
  Pages 3058 - 3064

Brief Report

• CDK2 is Dispensable for Adult Hippocampal Neurogenesis

  Renaud Vandenbosch, Laurence Borgs, Pierre Beukelaers, Agnès Foidart, Laurent Nguyen, Gustave Moonen, Cyril Berthet, Philipp Kaldis, Vittorio Gallo, Shibeshih Belachew and Brigitte Malgrange
  Pages 3065 - 3069

Reports

• The E3 Ubiquitin Ligase EDD Regulates S-Phase and G₂/M DNA Damage Checkpoints

  Marcia A. Munoz, Darren N. Saunders, Michelle J. Henderson, Jennifer L. Clancy, Amanda J. Russell, Gillian Lehrbach, Elizabeth A. Musgrove, Colin K.W. Watts and Robert L. Sutherland
  Pages 3070 - 3077

• Bilirubin Inhibits Tumor Cell Growth via Activation of ERK

  Robert Ollinger, Pamela Kogler, Jakob Troppmair, Martin Hermann, Martin Wurm, Astrid Drasche, Ingmar Konigsrainer, Albert Amberger, Helmut Weiss, Dietmar Ofner, Fritz H. Bach and Raimund Margreiter
  Pages 3078 - 3085

• Staurosporine Sensitizes T Lymphoma Cells to Glucocorticoid-Induced Apoptosis: Role of Nur77 and Bcl-2

  Shlomit Kfir, Ronit Vogt Sionov, Elazar Zafrirv, Yael Zilberman and Eitan Yefenof
  Pages 3086 - 3096

• Cytostatic and Cytotoxic Properties of Amphinase: A Novel Cytotoxic Ribonuclease from Rana pipiens Oocytes

  Barbara Ardelt, Wojciech Ardelt, Piotr Pozarowski, Jan Kunicki, Kuslima Shogen and Zbigniew Darzynkiewicz
  Pages 3097 - 3102

• Apaf-1 Deficiency Causes Chromosomal Instability

  Shahul Mouhamad, Lorenzo Galluzzi, Yael Zermati, Maria Castedo and Guido Kroemer
  Pages 3103 - 3107

• High NaCl Promotes Cellular Senescence

  Natalia I. Dmitrieva and Maurice B. Burg
  Pages 3108 - 3113

• The Cyclin-Dependent Kinase Inhibitor Seliciclib (R-roscovitine; CYC202) Decreases the Expression of Mitotic Control Genes and Prevents Entry into Mitosis

  Steven R. Whittaker, Robert H. te Poele, Florence Chan, Spiros Linardopoulos, Michael I. Walton, Michelle D. Garrett and Paul Workman
  Pages 3114 - 3131

• Nitric Oxide Coordinates Cell Proliferation and Cell Movements During Early Development of Xenopus

  Open Access Article

  Natalia Peunova, Vladimir Scheinker, Kandasamy Ravi and Grigori Enikolopov
  Pages 3132 - 3144

Letter to the Editor

• Multiple Kinases and System Robustness: A Link Between Cdc37 and Genome Integrity

  Open Access Article

  Avrom J. Caplan, Avi Ma'ayan and Ian M. Willis
  Pages 3145 - 3147