Table of Contents

Volume 4, Issue 12

  December 2005

  Pages 1693 - 1869

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Review of Concept

• Why Therapeutic Response May Not Prolong the Life of a Cancer Patient: Selection for Oncogenic Resistance

  Mikhail V. Blagosklonny
  Pages 1693 - 1698

Extra Views

• SUMO Keeps a Check on Recombination during DNA Replication

  Helle D. Ulrich, Sabina Vogel and Adelina A. Davies
  Pages 1699 - 1702

• PTPRV is a Key Mediator of p53-Induced Cell Cycle Exit

  Gilles Doumont, Alain Martoriati and Jean-Christophe Marine
  Pages 1703 - 1705

• New Talents for an Old Acquaintance: the SR Protein Splicing Factor ASF/SF2 Functions in the Maintenance of Genome Stability

  Xialu Li and James L. Manley
  Pages 1706 - 1708

• Cytokinesis and the Spindle Midzone

  Open Access Article

  Henrik Bringmann
  Pages 1709 - 1712

• ATP-Dependent Chromatin-Remodeling Complexes in DNA Double-Strand Break Repair: Remodeling, Pairing and (Re)pairing

  Jian Huang, Bing Liang, Jiajing Qiu and Brehon C. Laurent
  Pages 1713 - 1715

• AML1-ETO Needs a Partner: New Insights into the Pathogenesis of t(8;21) Leukemia

  F. Kuchenbauer, M. Feuring–Buske and C. Buske
  Pages 1716 - 1718

• The Intersection of Inheritance and Metastasis: The Role and Implications of Germline Polymorphism in Tumor Dissemination

  Kent Hunter
  Pages 1719 - 1721

• The Senescent Side of Tumor Suppression

  Manuel Collado and Manuel Serrano
  Pages 1722 - 1724

Perspectives

• CDK-Dependent Stabilization of Cdc6: Linking Growth and Stress Signals to Activation of DNA Replication

  Open Access Article

  Anja M. Duursma and Reuven Agami
  Pages 1725 - 1728

• Thrombopoietin Stimulates Vascular Endothelial Cell Growth factor (VEGF) Production in Hematopoietic Stem Cells

  Keita Kirito and Kenneth Kaushansky
  Pages 1729 - 1731

• From Immature Lamin to Premature Aging: Molecular Pathways and Therapeutic Opportunities

  Juan Cadiñanos, Ignacio Varela, Carlos López-Otín and José M. P. Freije
  Pages 1732 - 1735

• Blimp1 and the Emergence of the Germ Line during Development in the Mouse

  Mitinori Saitou, Bernhard Payer, Dónal O’Carroll, Yasuhide Ohinata and M. Azim Surani
  Pages 1736 - 1740

• Histone Deacetylase Inhibition Induces Apoptosis in Neuroblastoma

  Chitra Subramanian, Anthony W. Opipari, Valerie P. Castle and Roland P.S. Kwok
  Pages 1741 - 1743

• Cancer Gene Discovery Using the Sleeping Beauty Transposon

  Timothy K. Starr and David A. Largaespada
  Pages 1744 - 1748

• Switching On-Off Snail: LOXL2 Versus GSK3?

  Héctor Peinado, Francisco Portillo and Amparo Cano
  Pages 1749 - 1752

Review

• G-CSF (Granulocyte-Colony Stimulating Factor) in the Central Nervous System

  Armin Schneider, Hans-Georg Kuhn and Wolf-Rüdiger Schäbitz
  Pages 1753 - 1757

Brief Reports

• Individual Adult Human Neurons Display Aneuploidy: Detection by Fluorescence In Situ Hybridization and Single Neuron PCR

  Svetlana D. Pack, Robert J. Weil, Alexander O. Vortmeyer, Weifen Zeng, Jie Li, Hiroaki Okamoto, Makoto Furuta, Evgenia Pak, Irina A. Lubensky, Edward H. Oldfield and Zhengping Zhuang
  Pages 1758 - 1760

• BCR-ABL Kinase Domain Mutations in Chronic Myeloid Leukemia: Not Quite Enough to Cause Resistance to Imatinib Therapy?

  Thoralf Lange, Byung Park, Stephanie G. Willis and Michael W. Deininger
  Pages 1761 - 1766

Methodological Report

• In situ Detection of Specific DNA Double Strand Breaks using Rolling Circle Amplification

  Jia Li, C.S.H. Young, Paul M. Lizardia and David F. Stern
  Pages 1767 - 1773

Reports

• Stathmin Prevents the Transition from a Normal to an Endomitotic Cell Cycle during Megakaryocytic Differentiation

  Camelia Iancu-Rubin, Chris A. Nasrallah and George F. Atweh
  Pages 1774 - 1782

• The Absence of p53 Aggravates Polyploidy and Centrosome Number Abnormality Induced by Aurora-C Overexpression

  Stéphanie Dutertre, Elise Hamard-Péron, Jean-Yves Cremet, Yann Thomas and Claude Prigent
  Pages 1783 - 1787

• Deciphering Transcriptional Regulatory Elements That Encode Specific Cell-Cycle Phasing by Comparative Genomics Analysis

  Chaim Linhart, Ran Elkon, Yosef Shiloh and Ron Shamir
  Pages 1788 - 1797

• Subcellular Localization of the Cyclin Dependent Kinase Inhibitor Sic1 is Modulated by the Carbon Source in Budding Yeast

  Riccardo L. Rossi, Vittoria Zinzalla, Andrea Mastriani, Marco Vanoni and Lilia Alberghina
  Pages 1798 - 1807

• Caveolin-1-Deficient Mice Have An Increased Mammary Stem Cell Population with Upregulation of Wnt/?-Catenin Signaling

  Federica Sotgia, Terence M. Williams, Alex W. Cohen, Carlo Minetti, Richard G. Pestell and Michael P. Lisanti
  Pages 1808 - 1816

• Loss of Caveolin-1 Causes the Hyper-Proliferation of Intestinal Crypt Stem Cells, with Increased Sensitivity to Whole Body ?-Radiation

  Jiangwei Li, Ghada. S. Hassan, Terence M. Williams, Carlo Minetti, Richard G. Pestell, Herbert B. Tanowitz, Philippe G. Frank, Federica Sotgia and Michael P. Lisanti
  Pages 1817 - 1825

• Mechanistic Insight into the Cdc28-related Protein Kinase Ime2 through Analysis of Replication Protein A Phosphorylation

  Dawn M. Clifford, Kara E. Stark, Kathryn E. Gardner, Susanne Hoffmann-Benning and George S. Brush
  Pages 1826 - 1833

• The GAR Motif of 53BP1 is Arginine Methylated by PRMT1 and is Necessary for 53BP1 DNA Binding Activity

  François-Michel Boisvert, Alexandre Rhie, Stéphane Richard and Aidan J. Doherty
  Pages 1834 - 1841

• Preferential Occurrence of Chromosome Breakpoints within Early Replicating Regions in Neuroblastoma

  Isabelle Janoueix-Lerosey, Philippe Hupé, Zofia Maciorowski, Philippe La Rosa, Gudrun Schleiermacher, Gaëlle Pierron, Stéphane Liva, Emmanuel Barillot and Olivier Delattre
  Pages 1842 - 1846

• Resistance to Microtubule-Stabilizing Drugs Involves Two Eventse: β-Tubulin Mutation in One Allele Followed by Loss of the Second Allele

  Yuefang Wang, Aurora O’Brate, Wei Zhou and Paraskevi Giannakakou
  Pages 1847 - 1853

• 53BP1 Oligomerization is Independent of its Methylation by PRMT1

  Melissa M. Adams, Bin Wang, Zhenfang Xia, Julio C. Morales, Xiongbin Lu, Lawrence A. Donehower, Daniel A. Bochar, Stephen J. Elledge and Phillip B. Carpenter
  Pages 1854 - 1861

• Similar Tumor Suppressor Gene Alteration Profiles in Asbestos-Induced Murine and Human Mesothelioma

  Céline Lecomte, Pascal Andujar, Annie Renier, Laurence Kheuang, Vincent Abramowski, Lucile Mellotte, Jocelyne Fleury-Feith, Jessica Zucman-Rossi, Marco Giovanni and Marie-Claude Jaurand
  Pages 1862 - 1869