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Table of Contents

1 May 2008

volume 7| issue 9



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Shedding light on an old mystery: Thalidomide suppresses survival pathways to induce limb defects

Jürgen Knobloch and Ulrich Rüther
Volume: 7 | Issue: 9

Hypoxia-inducible factor signaling in the development of tissue fibrosis

Debra F. Higgins, Kuniko Kimura, Masayuki Iwano and Volker H. Haase
Volume: 7 | Issue: 9

Caspase 2 is both required for p53-mediated apoptosis and downregulated by p53 in a p21-dependent manner

Nicole Baptiste-Okoh, Anthony M. Barsotti and Carol Prives
Volume: 7 | Issue: 9

Is NHEJ a tumor suppressor or an aging suppressor?

Paul Hasty
Volume: 7 | Issue: 9

PERK and PKR: Old kinases learn new tricks

Jennifer F. Raven and Antonis E. Koromilas
Volume: 7 | Issue: 9

Insights into the oncogenic effects of /PIK3CA/ mutations from the structure of p110α/p85α

Chuan-Hsiang Huang, Diana Mandelker, Sandra B. Gabelli and L. Mario Amzel
Volume: 7 | Issue: 9

c-Met inhibitors with different binding modes: Two is better than one

Isabelle Dussault and Steven F. Bellon
Volume: 7 | Issue: 9

Telomeres: The silence is broken

Claus M. Azzalin and Joachim Lingner
Volume: 7 | Issue: 9

Perspectives

ESCRT functions in autophagy and associated disease

Tor Erik Rusten and Anne Simonsen
Volume: 7 | Issue: 9

Epigenetic inheritance of cell differentiation status

Ray K. Ng and John B. Gurdon
Volume: 7 | Issue: 9

Butyrate and Wnt signaling: a possible solution to the puzzle of dietary fiber and colon cancer risk?

Michael Bordonaro, Darina L. Lazarova and Alan C. Sartorelli
Volume: 7 | Issue: 9

Brief Report

The nucleolar phosphatase Cdc14B is dispensable for chromosome segregation and mitotic exit in human cells

Eli Berdougo, Maxence V. Nachury, Peter K. Jackson and Prasad V. Jallepalli
Volume: 7 | Issue: 9

Wnt signaling and adipocyte lineage commitment

Robert R. Bowers and M. Daniel Lane
Volume: 7 | Issue: 9

Priority Report

Disruption of the circadian clock due to the Clock mutation has discrete effects on aging and carcinogenesis

Marina P. Antoch, Victoria Y. Gorbacheva, Olena Vykhovanets, Illia A. Toshkov, Roman V. Kondratov, Anna A. Kondratova, Choogon Lee and Alexander Yu Nikitin
Volume: 7 | Issue: 9

Reports

A role of HAUSP in tumor suppression in a human colon carcinoma xenograft model

Kerstin Becker, Natalia D. Marchenko, Gustavo Palacios and Ute M. Moll
Volume: 7 | Issue: 9

p73-mediated transcriptional activity is negatively regulated by Polo-like kinase 1

Surinder M. Soond, Sean Barry, Gerry Melino, Richard A. Knight, David S. Latchman and Anastasis Stephanou
Volume: 7 | Issue: 9

Inhibition of p73 function by Pifithrin-α as revealed by studies in zebrafish embryos

William Davidson, Qing Ren, Gabor Kari, Ori Kashi, Adam P. Dicker and Ulrich Rodeck
Volume: 7 | Issue: 9

U-box-type ubiquitin E4 ligase, UFD2a attenuates cisplatin mediated degradation of ΔNp63α

Aditi Chatterjee, Sunil Upadhyay, Xiaofei Chang, Jatin K. Nagpal, Barry Trink and David Sidransky
Volume: 7 | Issue: 9

Paternal cranial irradiation induces distant bystander DNA damage in the germline and leads to epigenetic alterations in the offspring

Jan Tamminga, Igor Koturbash, Mike Baker, Kristy Kutanzi, Palak Kathiria, Igor P. Pogribny, Robert J. Sutherland and Olga Kovalchuk
Volume: 7 | Issue: 9

Protein complexes at the microtubule organizing center regulate bipolar spindle assembly

Adrianna S. Rodriguez, Alison N. Killilea, Joseph Batac, Jason Filopei, Dimitre Simeonov, Ida Lin and Janet L. Paluh
Volume: 7 | Issue: 9

The CCN3 gene coding for an extracellular adhesion-related protein is transcriptionally activated by the p53 tumor suppressor

Levin Böhlig, Roman Metzger, Karen Rother, Holger Till and Kurt Engeland
Volume: 7 | Issue: 9

Distinct roles for p107 and p130 in Rb-independent cellular senescence

Brian D. Lehmann, Adam M. Brooks, Matthew S. Paine, William H. Chappell, James A. McCubrey and David M. Terrian
Volume: 7 | Issue: 9

The Flp1/Clp1 phosphatase cooperates with HECT-type Pub1/2 protein-ubiquitin ligases in Schizosaccharomyces pombe

Verónica Esteban, María Sacristán, Sonia Andrés and Avelino Bueno
Volume: 7 | Issue: 9

Irreversible chromosome damage accumulates rapidly in the absence of ATM kinase activity

Jason S. White, Serah Choi and Christopher J. Bakkenist
Volume: 7 | Issue: 9

Cyclin B1 is rate limiting but not essential for mitotic entry and progression in mammalian somatic cells

Deena V. Soni, R. Michael Sramkoski, Minh Lam, Tammy Stefan and James W. Jacobberger
Volume: 7 | Issue: 9

Letter to the Editor

Cdc25A promotes G2/M transition in oocytes

Mo Li, Shen Yin, Ju Yuan, Liang Wei, Jun-Shu Ai, Yi Hou, Da-Yuan Chen and Qing-Yuan Sun
Volume: 7 | Issue: 9