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Table of Contents

december 2005

volume 4| issue 12



Review of Concept

Why Therapeutic Response May Not Prolong the Life of a Cancer Patient: Selection for Oncogenic Resistance

Mikhail V. Blagosklonny
Volume: 4 | Issue: 12 | Pages: 1693 - 1698

Open Access Article



Extra Views

SUMO Keeps a Check on Recombination during DNA Replication

Helle D. Ulrich, Sabina Vogel and Adelina A. Davies
Volume: 4 | Issue: 12 | Pages: 1699 - 1702

Open Access Article


PTPRV is a Key Mediator of p53-Induced Cell Cycle Exit

Gilles Doumont, Alain Martoriati and Jean-Christophe Marine
Volume: 4 | Issue: 12 | Pages: 1703 - 1705

Open Access Article


New Talents for an Old Acquaintance: the SR Protein Splicing Factor ASF/SF2 Functions in the Maintenance of Genome Stability

Xialu Li and James L. Manley
Volume: 4 | Issue: 12 | Pages: 1706 - 1708

Open Access Article


Cytokinesis and the Spindle Midzone

Henrik Bringmann
Volume: 4 | Issue: 12 | Pages: 1709 - 1712

Open Access Article


ATP-Dependent Chromatin-Remodeling Complexes in DNA Double-Strand Break Repair: Remodeling, Pairing and (Re)pairing

Jian Huang, Bing Liang, Jiajing Qiu and Brehon C. Laurent
Volume: 4 | Issue: 12 | Pages: 1713 - 1715

Open Access Article


AML1-ETO Needs a Partner: New Insights into the Pathogenesis of t(8;21) Leukemia

F. Kuchenbauer, M. Feuring–Buske and C. Buske
Volume: 4 | Issue: 12 | Pages: 1716 - 1718

Open Access Article


The Intersection of Inheritance and Metastasis: The Role and Implications of Germline Polymorphism in Tumor Dissemination

Kent Hunter
Volume: 4 | Issue: 12 | Pages: 1719 - 1721

Open Access Article


The Senescent Side of Tumor Suppression

Manuel Collado and Manuel Serrano
Volume: 4 | Issue: 12 | Pages: 1722 - 1724

Open Access Article



Perspectives

CDK-Dependent Stabilization of Cdc6: Linking Growth and Stress Signals to Activation of DNA Replication

Anja M. Duursma and Reuven Agami
Volume: 4 | Issue: 12 | Pages: 1725 - 1728

Open Access Article


Thrombopoietin Stimulates Vascular Endothelial Cell Growth factor (VEGF) Production in Hematopoietic Stem Cells

Keita Kirito and Kenneth Kaushansky
Volume: 4 | Issue: 12 | Pages: 1729 - 1731

Open Access Article


From Immature Lamin to Premature Aging: Molecular Pathways and Therapeutic Opportunities

Juan Cadiñanos, Ignacio Varela, Carlos López-Otín and José M. P. Freije
Volume: 4 | Issue: 12 | Pages: 1732 - 1735

Open Access Article


Blimp1 and the Emergence of the Germ Line during Development in the Mouse

Mitinori Saitou, Bernhard Payer, Dónal O’Carroll, Yasuhide Ohinata and M. Azim Surani
Volume: 4 | Issue: 12 | Pages: 1736 - 1740

Open Access Article


Histone Deacetylase Inhibition Induces Apoptosis in Neuroblastoma

Chitra Subramanian, Anthony W. Opipari, Valerie P. Castle and Roland P.S. Kwok
Volume: 4 | Issue: 12 | Pages: 1741 - 1743

Open Access Article


Cancer Gene Discovery Using the Sleeping Beauty Transposon

Timothy K. Starr and David A. Largaespada
Volume: 4 | Issue: 12 | Pages: 1744 - 1748

Open Access Article


Switching On-Off Snail: LOXL2 Versus GSK3?

Héctor Peinado, Francisco Portillo and Amparo Cano
Volume: 4 | Issue: 12 | Pages: 1749 - 1752

Open Access Article



Review

G-CSF (Granulocyte-Colony Stimulating Factor) in the Central Nervous System

Armin Schneider, Hans-Georg Kuhn and Wolf-Rüdiger Schäbitz
Volume: 4 | Issue: 12 | Pages: 1753 - 1757

Open Access Article



Brief Report

Individual Adult Human Neurons Display Aneuploidy: Detection by Fluorescence In Situ Hybridization and Single Neuron PCR

Svetlana D. Pack, Robert J. Weil, Alexander O. Vortmeyer, Weifen Zeng, Jie Li, Hiroaki Okamoto, Makoto Furuta, Evgenia Pak, Irina A. Lubensky, Edward H. Oldfield and Zhengping Zhuang
Volume: 4 | Issue: 12 | Pages: 1758 - 1760

Open Access Article


BCR-ABL Kinase Domain Mutations in Chronic Myeloid Leukemia: Not Quite Enough to Cause Resistance to Imatinib Therapy?

Thoralf Lange, Byung Park, Stephanie G. Willis and Michael W. Deininger
Volume: 4 | Issue: 12 | Pages: 1761 - 1766

Open Access Article



Methodological Report

In situ Detection of Specific DNA Double Strand Breaks using Rolling Circle Amplification

Jia Li, C.S.H. Young, Paul M. Lizardia and David F. Stern
Volume: 4 | Issue: 12 | Pages: 1767 - 1773

Open Access Article



Report

Stathmin Prevents the Transition from a Normal to an Endomitotic Cell Cycle during Megakaryocytic Differentiation

Camelia Iancu-Rubin, Chris A. Nasrallah and George F. Atweh
Volume: 4 | Issue: 12 | Pages: 1774 - 1782

Open Access Article


The Absence of p53 Aggravates Polyploidy and Centrosome Number Abnormality Induced by Aurora-C Overexpression

Stéphanie Dutertre, Elise Hamard-Péron, Jean-Yves Cremet, Yann Thomas and Claude Prigent
Volume: 4 | Issue: 12 | Pages: 1783 - 1787

Open Access Article


Deciphering Transcriptional Regulatory Elements That Encode Specific Cell-Cycle Phasing by Comparative Genomics Analysis

Chaim Linhart, Ran Elkon, Yosef Shiloh and Ron Shamir
Volume: 4 | Issue: 12 | Pages: 1788 - 1797

Open Access Article


Subcellular Localization of the Cyclin Dependent Kinase Inhibitor Sic1 is Modulated by the Carbon Source in Budding Yeast

Riccardo L. Rossi, Vittoria Zinzalla, Andrea Mastriani, Marco Vanoni and Lilia Alberghina
Volume: 4 | Issue: 12 | Pages: 1798 - 1807

Open Access Article


Caveolin-1-Deficient Mice Have An Increased Mammary Stem Cell Population with Upregulation of Wnt/?-Catenin Signaling

Federica Sotgia, Terence M. Williams, Alex W. Cohen, Carlo Minetti, Richard G. Pestell and Michael P. Lisanti
Volume: 4 | Issue: 12 | Pages: 1808 - 1816

Open Access Article


Loss of Caveolin-1 Causes the Hyper-Proliferation of Intestinal Crypt Stem Cells, with Increased Sensitivity to Whole Body ?-Radiation

Jiangwei Li, Ghada. S. Hassan, Terence M. Williams, Carlo Minetti, Richard G. Pestell, Herbert B. Tanowitz, Philippe G. Frank, Federica Sotgia and Michael P. Lisanti
Volume: 4 | Issue: 12 | Pages: 1817 - 1825

Open Access Article


Mechanistic Insight into the Cdc28-related Protein Kinase Ime2 through Analysis of Replication Protein A Phosphorylation

Dawn M. Clifford, Kara E. Stark, Kathryn E. Gardner, Susanne Hoffmann-Benning and George S. Brush
Volume: 4 | Issue: 12 | Pages: 1826 - 1833

Open Access Article


The GAR Motif of 53BP1 is Arginine Methylated by PRMT1 and is Necessary for 53BP1 DNA Binding Activity

François-Michel Boisvert, Alexandre Rhie, Stéphane Richard and Aidan J. Doherty
Volume: 4 | Issue: 12 | Pages: 1834 - 1841

Open Access Article


Preferential Occurrence of Chromosome Breakpoints within Early Replicating Regions in Neuroblastoma

Isabelle Janoueix-Lerosey, Philippe Hupé, Zofia Maciorowski, Philippe La Rosa, Gudrun Schleiermacher, Gaëlle Pierron, Stéphane Liva, Emmanuel Barillot and Olivier Delattre
Volume: 4 | Issue: 12 | Pages: 1842 - 1846

Open Access Article


Resistance to Microtubule-Stabilizing Drugs Involves Two Eventse: β-Tubulin Mutation in One Allele Followed by Loss of the Second Allele

Yuefang Wang, Aurora O’Brate, Wei Zhou and Paraskevi Giannakakou
Volume: 4 | Issue: 12 | Pages: 1847 - 1853

Open Access Article


53BP1 Oligomerization is Independent of its Methylation by PRMT1

Melissa M. Adams, Bin Wang, Zhenfang Xia, Julio C. Morales, Xiongbin Lu, Lawrence A. Donehower, Daniel A. Bochar, Stephen J. Elledge and Phillip B. Carpenter
Volume: 4 | Issue: 12 | Pages: 1854 - 1861

Open Access Article


Similar Tumor Suppressor Gene Alteration Profiles in Asbestos-Induced Murine and Human Mesothelioma

Céline Lecomte, Pascal Andujar, Annie Renier, Laurence Kheuang, Vincent Abramowski, Lucile Mellotte, Jocelyne Fleury-Feith, Jessica Zucman-Rossi, Marco Giovanni and Marie-Claude Jaurand
Volume: 4 | Issue: 12 | Pages: 1862 - 1869

Open Access Article