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Don't Skip the G1 Phase: How APC/CCdh1 Keeps SCFSKP2 in Check
Tarig Bashir and Michele Pagano
volume 3 | issue 7
july 2004Pages: 850 - 852
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By keeping the levels of Skp2 and Cks1 low during G1 progression, APC/CCdh1 prevents unscheduled degradation of SCFSkp2 substrates and premature entry into S phase. Thus, APC/CCdh1, a ubiquitin ligase involved in mitotic exit and maintenance of G0/G1 phase, directly controls SCFSKP2, a ubiquitin ligase involved in the regulation of S phase entry.
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.