Exploiting synthetic lethal interactions for targeted cancer therapy
Volume 8, Issue 19
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October 1, 2009
Pages 3112 - 3119http://dx.doi.org/10.4161/cc.8.19.9626
Authors: H. Christian Reinhardt, Hai Jiang, Michael T. Hemann and Michael B. Yaffe View affiliations
Emerging data suggests that synthetic lethal interactions between mutated oncogenes/tumor suppressor genes and molecules involved in DNA damage signaling and repair can be therapeutically exploited to preferentially kill tumor cells. In this review, we discuss the concept of synthetic lethality, and describe several recent examples in which this concept was successfully implemented to target tumor cells in culture, in mouse models, and in human cancer patients.