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Coordination of DNA Synthesis and Histone Gene Expression During Normal Cell Cycle Progression and After DNA Damage
Jiyong Zhao
volume 3 | issue 6
june 2004Pages: 695 - 697
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Chromosomal DNA replication and histone synthesis are tightly coupled during S phase of the eukaryotic cell division cycle. Recently we reported that mRNA levels of mammalian replication-dependent histones, both linker histone H1 and four core histones (H2A, H2B, H3 and H4), are coordinately down-regulated in parallel with the inhibition of DNA synthesis upon DNA damage. Moreover, we showed that ionizing radiation induces inhibition of histone gene transcription through the G1 checkpoint pathway. These results demonstrate that histone synthesis is coordinated with DNA synthesis not only under normal growth conditions but also under conditions where DNA damage may occur. Regulation of the cyclin E-Cdk2 substrate NPAT, which is essential for both histone gene expression and S phase entry, provides a mechanism coordinating histone and DNA synthesis in mammalian cells.
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.