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Perspectives
Hard Wired Genotype in Metastatic Breast Cancer
Britta Weigelt and Laura J. van 't' Veer
volume 3 | issue 6
june 2004Pages: 756 - 757
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Recently, we showed by gene-expression profiling that the molecular program established in a human primary breast carcinoma is highly preserved in its distant metastases. According to the predominant model of metastasis, the capacity of a primary tumor to metastasize is acquired only rarely and late in tumorigenesis. Our findings challenge this common theory and imply that the metastatic nature of ‘poor prognosis profile’ breast carcinomas is an inherent feature, and not reserved to advantageous subpopulations.
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.