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Multiple Roles of Canonical Wnt Signaling in Cell Cycle Progression and Cell Lineage Specification in Neural Development
Lukas Sommer
volume 3 | issue 6
june 2004Pages: 701 - 703
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Signaling by the canonical Wnt pathway has multiple functions in stem cells. It can either control stem cell expansion or –as we have recently demonstrated with neural crest stem cells– influence cell lineage decisions by promoting specific fates at the expense of others. Thus, the role of canonical Wnt in stem cells is dependent on cell-intrinsic properties that determine how a cell responds to Wnt. The molecular basis for the functional diversity of Wnt in different stem cell types remains to be elucidated.
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.