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Perspectives
p53 Designer Genes for the Modern Mouse
Manfred Hergenhahn, Jun-Li Luo and Monica Hollstein
volume 3 | issue 6
june 2004Pages: 738 - 741
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Major efforts are underway to develop molecular strategies that target the p53 pathway for the treatment of cancer. Mouse strains with humanized p53 sequences, which presents the precise human DNA-binding domain as mutation target, could be informative models to test p53 rescue drugs, and to explore experimentally the causes of human tumor mutations.
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.