At concentrations that inhibit mTOR, resveratrol suppresses cellular senescence
Volume 8, Issue 12
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June 15, 2009
Pages 1901 - 1904http://dx.doi.org/10.4161/cc.8.12.8810
Authors: Zoya N. Demidenko and Mikhail V. Blagosklonny View affiliations
Here we demonstrated that, at cytostatic, near-toxic concentrations, resveratrol inhibited S6 phosphorylation and prevented the senescence morphology in human cells. Using a sensitive functional assay, we found that resveratrol partially prevented loss of the proliferative potential associated with cellular senescence. Resveratrol was less effective than rapamycin, because aging-suppression by resveratrol was limited by its toxicity at high concentrations. We discuss whether concentrations of resveratrol that inhibit mTOR (target of rapamycin) and suppress cellular senescence are clinically achievable and whether partial inhibition of mTOR by resveratrol might be sufficient to affect organismal aging.
Received: March 28, 2009; Accepted: April 21, 2009