Report

Interleukin-6 affects cell death escaping mechanisms acting on Bax-Ku70-Clusterin interactions in human colon cancer progression

Volume 8, Issue 3   February 1, 2009
Pages 473 - 481
http://dx.doi.org/10.4161/cc.8.3.7652
Authors: Sabina Pucci, Paola Mazzarelli, Fabiola Sesti, David A. Boothman and Luigi G. Spagnoli

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Abstract:
Activation of pro-survival pathways and apoptotic cell death escape are considered hallmarks of oncogenic cell transformation. Tissue microenvironment strongly influences tumorigenesis, redirecting some pathways versus a persisting pro-survival state. Here, we report evidence on the role of interleukin 6 (IL-6)  in affecting  pro-survival pathways in  colon cancer progression, modulating the expression and the molecular interactions among the pro-apoptotic factor Bax, the  DNA repair proteins Ku70/86 and Clusterin isoforms.

Received: December 15, 2008; Accepted: December 18, 2008

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