Interleukin-6 affects cell death escaping mechanisms acting on Bax-Ku70-Clusterin interactions in human colon cancer progression
Volume 8, Issue 3
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February 1, 2009
Pages 473 - 481http://dx.doi.org/10.4161/cc.8.3.7652
Authors: Sabina Pucci, Paola Mazzarelli, Fabiola Sesti, David A. Boothman and Luigi G. Spagnoli View affiliations
Activation of pro-survival pathways and apoptotic cell death escape are considered hallmarks of oncogenic cell transformation. Tissue microenvironment strongly influences tumorigenesis, redirecting some pathways versus a persisting pro-survival state. Here, we report evidence on the role of interleukin 6 (IL-6) in affecting pro-survival pathways in colon cancer progression, modulating the expression and the molecular interactions among the pro-apoptotic factor Bax, the DNA repair proteins Ku70/86 and Clusterin isoforms.
Received: December 15, 2008; Accepted: December 18, 2008