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An ArfGFP/GFP Indicator Mouse Reveals that the Arf Tumor Suppressor Monitors Latent Oncogenic Signals In Vivo
Charles J. Sherr
volume 3 | issue 3
mar 2004Pages: 239 - 240
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Understanding how the Arf tumor suppressor is activated in response to abnormally elevated mitogenic signaling thresholds is a particularly vexing problem. Studies of a knock-in mouse strain in which sequences encoding green fluorescent protein were substituted for those encoding p19Arf argue that the Arf gene responds to latent oncogenic signals in vivo to eliminate incipient cancer cells.
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.